XIAP-Associated Factor 1

Preferred Label : XIAP-Associated Factor 1;

NCIt synonyms : ZAP-1; XAF1; BIRC4-Binding Protein; XIAP-Associated Factor-1;

NCIt definition : XIAP-associated factor 1 (301 aa, 35 kDa) is encoded by the human XAF1 gene. This protein plays a role in the regulation of apoptosis.;

NCIt note : Widely expressed (highest in heart, ovary; lowest in brain, testis) by human XAF1 Gene (IAP Family), 317-aa 37-kDa XIAP-Associated Factor 1 contains 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI);

Details

Origin ID

C20929;

UMLS CUI

C1447833;

OMIM relation
- Xiap-associated factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XAF1 protein, human [MeSH concept]
- XAF1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- XAF1 Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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