Preferred Label : Orphan Nuclear Receptor Gene;
NCIt definition : Orphan Nuclear Receptor Genes (NR Superfamily) encode numerous Orphan Nuclear Receptor
(NRs) transcription factors thought to be activated by as yet unknown ligands. Transducing
cellular signals into gene transcription, NRs regulate development, pattern formation,
cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share
a common organization: an (N) modulatory domain, a conserved central Cys-rich region
of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA
elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions
contribute to DNA binding specificity, homodimerization, and interaction with other
proteins. Ligand-bound NR conformation allows coactivator interaction with the ligand-binding
domain that mediates interaction with heat shock proteins, cyclophilins, and ligand.
(NCI);
Origin ID : C20708;
UMLS CUI : C1335143;
See also inter- (CISMeF)
- Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
