Lymphotoxin-Beta

Preferred Label : Lymphotoxin-Beta;

NCIt synonyms : Lymphotoxin Beta; LTB; LTB Protein; TNFC; LT-Beta; Tumor Necrosis Factor C; TNF-C; Tumor Necrosis Factor Ligand Superfamily Member 3; LTbeta; Tumor Necrosis Factor-C; TNFSF3;

NCIt definition : Lymphotoxin-beta (244 aa, 25 kDa) is encoded by the human LTB gene. This protein is involved in cell-cell signaling and immune responses.;

NCIt note : The lymphotoxin complex is comprised of a heterotrimer of either two lymphotoxin-beta (LTB) and one lymphotoxin-alpha (LTA) subunits or one LTB and two LTA subunits; the latter complex is less prevalent. (UniProt);

Details

Origin ID

C20530;

UMLS CUI

C1664181;

OMIM relation
- Lymphotoxin-beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LTB protein, human [MeSH concept]
- LTB protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- lymphotoxin-beta [MeSH Descriptor]
- lymphotoxin-beta [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- LTB Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_expressed_in_tissue
- Spleen [NCIt concept]
- Thymus Gland [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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