Cardiac Phospholamban

Preferred Label : Cardiac Phospholamban;

NCIt synonyms : Phospholamban; PLN; PLB;

NCIt definition : Cardiac phospholamban (52 aa, 6 kDa) is encoded by the human PLN gene. This protein is involved in contractility of the heart muscle through the regulation of calcium transport by sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2).;

NCIt note : Cardiac phospholamban (PLN) forms pentamers localized to sarcoplasmic reticulum membranes. PLN inhibits calcium transport by sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2); inhibition is relieved upon phosphorylation of PLN by protein kinase A. (EntrezGene, OMIM and UniProt);

Details

Origin ID

C204500;

UMLS CUI

C1453157;

OMIM relation
- Phospholamban [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PLN protein, human [MeSH concept]
gene_encodes_gene_product
- PLN Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Myocardium [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Mitochondrial Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
- Sarcoplasmic Reticulum [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Blood Circulation [NCIt concept]
- Calcium Homeostasis [NCIt concept]
- Cardiac Muscle Contraction [NCIt concept]
- Myogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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