Peroxisomal ATPase PEX6

Preferred Label : Peroxisomal ATPase PEX6;

NCIt synonyms : Peroxisome Assembly Factor 2; PEX6; Peroxin-6; Peroxisomal-Type ATPase 1; PAF-2; Peroxisome Biogenesis Factor 6; Peroxisomal Biogenesis Factor 6; EC 3.6.4.-; Peroxin 6;

NCIt definition : Peroxisomal ATPase PEX6 (980 aa, 104 kDa) is encoded by the human PEX6 gene. This protein is involved in recycling of the peroxisomal targeting signal 1 receptor (PEX5).;

NCIt note : Peroxisomal ATPase PEX6 interacts with peroxisomal ATPase PEX1 to form the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by three of PEX1-PEX6 heterodimers. The recruitment of PEX1-PEX6 AAA ATPase complex to peroxisome membranes is promoted by interaction with peroxisome assembly protein 26 (PEX26). (UniProt);

Details

Origin ID

C204457;

UMLS CUI

C1455046;

OMIM relation
- Peroxisome biogenesis factor 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PEX6 protein, human [MeSH Supplementary Concept]
- PEX6 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- PEX6 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Cytoplasm [NCIt concept]
- Membrane of the Peroxisome [NCIt concept]
- Outer Segment of the Photoreceptor Cell [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Peroxisome Biogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Hydrolysis [NCIt concept]
- Ligand Binding [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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