Preferred Label : Anti-B7-H4/Anti-4-1BB Bispecific Antibody ABL103;
NCIt synonyms : TCE ABL103; B7-H4x4-1BB Bispecific Antibody ABL103; Anti-B7-H4/4-1BB Bispecific Antibody ABL103; Anti-4-1BB/B7-H4 Bispecific Antibody ABL103; ABL103, B7-H4 Grabody-T ABL103; Anti-4-1BB/Anti-B7-H4 Bispecific Antibody ABL103; 4-1BB x B7-H4 Bispecific Antibody ABL103;
NCIt definition : A T-cell engaging (TCE) bispecific antibody against both the tumor-associated antigen
(TAA) B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1)
and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily
member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic
activities. Upon administration, anti-B7-H4/anti-4-1BB bispecific antibody ABL103
targets and binds to both B7-H4 expressed on the surface of tumor cells and 4-1BB
expressed on immune cells, including activated T-lymphocytes, natural killer (NK)
cells and NK-T-cells. This crosslinks B7-H4-expressing tumor cells and 4-1BB-expressing
T-cells, NK cells and NK-T-cells, and activates 4-1BB signaling locally in the tumor
microenvironment (TME) only when in the presence of B7-H4 expressing cells. This induces
cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated
anti-tumor immune response against tumor cells, induces NK-mediated tumor cell killing,
and suppresses the immunosuppressive activity of regulatory T-cells (Tregs). In addition,
the blockage of B7-H4 by ABL103 directly prevents B7-H4-mediated inhibition of T-cells.
B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety
of tumor cell types and negatively regulates T-cell immune responses. B7-H4 expression
in normal tissues is quite limited. 4-1BB, a surface glycoprotein of the tumor necrosis
factor receptor superfamily, is an inducible costimulatory receptor that plays a key
role in T-cell proliferation, survival and cytolytic activity.;
Molecule name : ABL 103; ABL-103;
NCI Metathesaurus CUI : CL1926436;
Origin ID : C204165;
UMLS CUI : C5908034;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
