Peptide-N(4)-(N-Acetyl-Beta-Glucosaminyl)Asparagine Amidase

Preferred Label : Peptide-N(4)-(N-Acetyl-Beta-Glucosaminyl)Asparagine Amidase;

NCIt synonyms : Peptide:N-Glycanase; EC 3.5.1.52; hPNGase; N-Glycanase 1; PNGase; NGLY1;

NCIt definition : Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (654 aa, 74 kDa) is encoded by the human NGLY1 gene. This protein is involved in catalyzing the deglycosylation of misfolded or denatured N-linked glycoproteins.;

NCI Metathesaurus CUI : CL790364;

Details

Origin ID

C203945;

UMLS CUI

C5890995;

OMIM relation
- N-glycanase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- NGLY1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Catabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Post-Translational Regulation [NCIt concept]
- Unfolded Protein Response [NCIt concept]

Keyword's position in hierarchy(ies) :

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