Glycoprotein Ib/IX Complex

Preferred Label : Glycoprotein Ib/IX Complex;

NCIt synonyms : Platelet Glycoprotein Ib/IX Complex; CD42ABC Complex; Complex Glycoprotein Ib-IX; GPIb-IX; GPIb/IX; Platelet Glycoprotein Ib-IX;

NCIt related terms : Platelet GPIb/Ix; PLATELET GLYCOPROTEIN IB/IX;

NCIt definition : A heterotetrameric, transmembrane protein complex consisting of three subunits, platelet glycoprotein (GP) 1b alpha (GPIba), GP 1b beta (GPIbb), and GPIX, which are organized in the platelet membrane in a ratio of 1:2:1. The two GPIbb subunits form disulfide bonds with GPIba and are non-covalently linked to GPIX. This complex is involved in platelet biogenesis, thrombin-mediated platelet aggregation, vonWillebrand factor-mediated platelet adhesion, mechanotransduction, platelet activation and blood clot formation. Antibodies targeting this complex are associated with autoimmune thrombocytopenic purpura.;

Alternative definition : CDISC: A glycoprotein complex and platelet surface receptor composed of the transmembrane GPIb and GPIX subunits. It mediates platelet adhesion, activation, clearance, and thrombopoiesis. This complex can be considered as an autoantigen and is commonly associated with autoimmune thrombocytopenic purpura.;

NCI Metathesaurus CUI : CL1922454;

Details

Origin ID

C203625;

UMLS CUI

C0017966;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Platelet glycoprotein Ib/Ix [LOINC component]
- platelet glycoprotein GPIb-IX complex [MeSH Descriptor]
- platelet glycoprotein GPIb-IX complex [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_product_plays_role_in_biological_process
- Platelet Activation [NCIt concept]
- Platelet Aggregation Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Thrombopoiesis [NCIt concept]
has_gene_product_element
- Platelet Glycoprotein IX [NCIt concept]
- Platelet Membrane Glycoprotein 1b Alpha Chain [NCIt concept]
- Platelet Membrane Glycoprotein 1b Beta Chain [NCIt concept]
related_to_genetic_biomarker
- GP1BA Gene [NCIt concept]
- GP1BB Gene [NCIt concept]
- GP9 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients