Preferred Label : platelet glycoprotein GPIb-IX complex;
MeSH definition : Platelet membrane glycoprotein complex essential for normal platelet adhesion and
clot formation at sites of vascular injury. It is composed of three polypeptides,
GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand
factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier
syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent
in Bernard-Soulier syndrome.;
MeSH synonym : glycoprotein ib-ix complex; glycoprotein ib ix complex; platelet glycoprotein GPIb IX complex;
MeSH hyponym : platelet membrane glycoprotein IX; CD42c antigens; CD42b antigens; platelet membrane glycoprotein ib; CD42d antigen; Glycoprotein Ib; Glycoprotein Ib beta; CD42c Antigen; Antigen, CD42c; Antigens, CD42c; Antigens, CD42b; Glycoprotein Ib alpha; CD42b Antigen; Antigen, CD42b; Antigen, CD42d; CD42d Antigens; Antigens, CD42d; CD42a Antigens; Antigens, CD42a; Platelet Glycoprotein IX; CD42a Antigen; Antigen, CD42a;
Related MeSH term : platelet membrane glycoprotein V;
MeSH annotation : important in platelet aggreg; note X refs as CD42 antigens; DF: GPIB IX;
Is substance : O;
Origin ID : D019038;
UMLS CUI : C0017966;
Allowable qualifiers
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- Record concept(s)
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- UMLS correspondences (same concept)
Platelet membrane glycoprotein complex essential for normal platelet adhesion and
clot formation at sites of vascular injury. It is composed of three polypeptides,
GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand
factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier
syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent
in Bernard-Soulier syndrome.
