Preferred Label : Emilumenib;
NCIt synonyms : Menin-MLL Interaction Inhibitor DS-1594a; Menin Inhibitor DS-1594a;
NCIt definition : An orally bioavailable small molecule inhibitor of menin, with potential antineoplastic
activity. Upon oral administration, menin inhibitor DS-1594b targets and binds to
the nuclear protein menin, thereby preventing the interaction between the two proteins
menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and
the formation of the menin-MLL complex. This reduces the expression of downstream
target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic
cells. The menin-MLL complex plays a key role in the survival, growth, transformation
and proliferation of certain kinds of leukemia cells.;
UNII : 4NXF6NCL6Z;
CAS number : 2440018-29-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2440018-29-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : DS 1594a; DS-1594a;
Origin ID : C203019;
concept_is_in_subset
- has_target
