Preferred Label : Emilumenib;
NCIt synonyms : Menin-MLL Interaction Inhibitor DS-1594a; Menin Inhibitor DS-1594a;
NCIt definition : An orally bioavailable small molecule inhibitor of menin, with potential antineoplastic
activity. Upon oral administration, emilumenib targets and binds to the nuclear protein
menin, thereby preventing the interaction between the two proteins menin and menin-mixed
lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and the formation of the
menin-MLL complex. This reduces the expression of downstream target genes and results
in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL
complex plays a key role in the survival, growth, transformation and proliferation
of certain kinds of leukemia cells.;
UNII : 4NXF6NCL6Z;
CAS number : 2440018-29-9;
Molecule name : DS 1594a; DS-1594a;
NCI Metathesaurus CUI : CL1922152;
Origin ID : C203019;
UMLS CUI : C5907990;
Semantic type(s)
- concept_is_in_subset
- has_target
