Preferred Label : Emilumenib Succinate;
NCIt synonyms : Menin-MLL Interaction Inhibitor DS-1594b; Menin Inhibitor DS-1594b;
NCIt definition : The succinate form of emilumenib, an orally bioavailable small molecule inhibitor
of menin, with potential antineoplastic activity. Upon oral administration, menin
inhibitor DS-1594b targets and binds to the nuclear protein menin, thereby preventing
the interaction between the two proteins menin and menin-mixed lineage leukemia (MLL;
myeloid/lymphoid leukemia; KMT2A) and the formation of the menin-MLL complex. This
reduces the expression of downstream target genes and results in an inhibition of
the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a
key role in the survival, growth, transformation and proliferation of certain kinds
of leukemia cells.;
UNII : 7J2B2NUJ27;
CAS number : 2440018-30-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2440018-30-2
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G-SRS /a ;
Molecule name : DS-1594b; DS-1594; DS 1594b;
NCI Metathesaurus CUI : CL1662388;
Origin ID : C179693;
UMLS CUI : C5555867;
Semantic type(s)
- concept_is_in_subset
- has_target
