NCIt definition : The succinate form of emilumenib, an orally bioavailable small molecule inhibitor
of menin, with potential antineoplastic activity. Upon oral administration, emilumenib
targets and binds to the nuclear protein menin, thereby preventing the interaction
between the two proteins menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid
leukemia; KMT2A) and the formation of the menin-MLL complex. This reduces the expression
of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged
leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation
and proliferation of certain kinds of leukemia cells.;
Semantic type(s)