C-Type Lectin Domain Family 6 Member A

Preferred Label : C-Type Lectin Domain Family 6 Member A;

NCIt synonyms : Dendritic Cell-Associated C-Type Lectin 2; C-Type Lectin Superfamily Member 10; DC-Associated C-Type Lectin 2; CLEC6A; C-Type Lectin Domain Containing 6A; Dectin-2; Dectin 2;

NCIt definition : C-type lectin domain family 6 member A (209 aa, 24 kDa) is encoded by the human CLEC6A gene. This protein is involved in pattern recognition receptor (PRR) activity.;

NCIt note : C-type lectin domain family 6 member A binds alpha-mannans on C.albicans hypheas and mannose-containing allergens from house dust mites and fungi. (UniProt);

NCI Metathesaurus CUI : CL1671511;

Details

Origin ID

C201950;

UMLS CUI

C5890870;

OMIM relation
- C-type lectin domain family 6, member a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- CLEC6A Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Bone Marrow [NCIt concept]
- Lymph Node [NCIt concept]
- Spleen [NCIt concept]
- Tonsil [NCIt concept]
gene_product_has_associated_anatomy
- Dendritic Cell [NCIt concept]
- Leukocyte [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Lectin [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antimicrobial Effect [NCIt concept]
- Cell-Mediated Immunity [NCIt concept]
- Immune System Process [NCIt concept]
- Ligand Binding [NCIt concept]
is_target
- Anti-dectin-2 Agonist Monoclonal Antibody BDC-3042 [NCIt concept]

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