Integral Membrane Protein 2B

Preferred Label : Integral Membrane Protein 2B;

NCIt synonyms : Immature BRI2; ITM2B; Transmembrane Protein BRI; Protein E25B; Bri; imBRI2;

NCIt definition : Integral membrane protein 2B (266 aa, 30 kDa) is encoded by the human ITM2B gene. This protein is involved in steric hinderance of amyloid-beta precursor protein cleavage by both beta- and gamma-secretases.;

NCIt note : Integral membrane protein 2B (immature BRI2; imBRI2) is cleaved by furin producing a secreted Bri23 peptide (Bri2-23; ABri23; C-terminal peptide; P23 peptide) and a mature membrane bound form, called BRI2, membrane form (mature BRI2; mBRI2). The remaining part of the ectodomain of mBRI2 can be cleaved by ADAM10 yielding a secreted form, called BRI2C, soluble form. The membrane-bound N-terminal fragment (BRI2, membrane form) is further proteolytically processed by signal peptide peptidase-like 2A and 2B through regulated intramembrane proteolysis producing a secreted C-peptide and releases BRI2 intracellular domain (BRI2 ICD) into the cytosol. (UniProt);

Details

Origin ID

C201836;

OMIM relation
- Integral membrane protein 2b [OMIM gene]
gene_encodes_gene_product
- ITM2B Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endosome [NCIt concept]
- Membrane of the Golgi Apparatus [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Nervous System Development [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

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