Extracellular Calcium-Sensing Receptor

Preferred Label : Extracellular Calcium-Sensing Receptor;

NCIt synonyms : PCaR1; Calcium-Sensing Receptor; CaR; CaSR; Parathyroid Cell Calcium-Sensing Receptor 1; Calcium Sensing Receptor; hCasR; Parathyroid Ca(2 )-Sensing Receptor 1;

NCIt definition : Extracellular calcium-sensing receptor (1078 aa, 121 kDa) is encoded by the human CASR gene. This protein is involved in calcium sensing, G-protein-coupled receptor signaling and the regulation of both parathyroid hormone secretion and renal cation reabsorption.;

Details

Origin ID

C201833;

UMLS CUI

C5890846;

OMIM relation
- Calcium-sensing receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- CASR Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- E-Cadherin Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Calcium Homeostasis [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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