Preferred Label : Anti-LAG-3/TIGIT Bispecific Antibody ZGGS15;
NCIt synonyms : Anti-LAG-3/Anti-TIGIT Bispecific Antibody ZGGS15; LAG-3 x TIGIT Bispecific Antibody ZGGS15; Anti-LAG-3 x Anti-TIGIT Bispecific Antibody ZGGS15;
NCIt definition : A bispecific antibody targeting the co-inhibitory receptor lymphocyte-activation gene
3 protein (LAG-3; LAG3; CD223) and the co-inhibitory molecule and immune checkpoint
inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based
inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory
and antineoplastic activities. Upon administration, anti-LAG-3/TIGIT bispecific antibody
ZGGS15 targets, binds to and blocks LAG-3 expressed by tumor infiltrating lymphocytes
(TILs), thereby preventing the interaction between LAG-3 and major histocompatibility
complex class II (MHC II) molecules on the surface of antigen-presenting cells (APCs)
and tumor cells. This prevents the negative regulation of T-cell activity that occurs
via LAG-3-MHC II binding and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune
response against tumor cells, leading to a reduction in tumor growth. In addition,
ZGGS15 simultaneously targets and binds to TIGIT expressed on various immune cells,
particularly on TILs, thereby preventing the interaction of TIGIT with its ligands
CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus
receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction of CD112
and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1),
which is expressed on immune cells, such as natural killer (NK) cells and CD8 T-cells.
This leads to CD226 dimerization and CD226-mediated signaling and activates the immune
system to further exert a T-cell-mediated immune response against cancer cells. LAG-3,
a member of the immunoglobulin superfamily (IgSF), negatively regulates both the proliferation
and activation of T-cells. Its expression on TILs is associated with tumor-mediated
immune suppression. TIGIT, a member of the IgSF and an immune inhibitory receptor,
plays a key role in the suppression of T-cell proliferation and activation; it is
involved in tumor cell immune evasion.;
Molecule name : ZG-GS15; ZG GS15;
NCI Metathesaurus CUI : CL1915155;
Origin ID : C200909;
UMLS CUI : C5854618;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
