Preferred Label : SRC/YES1 Kinase Inhibitor NXP900;
NCIt synonyms : SFK Inhibitor NXP900; SRC Family Kinase Inhibitor NXP900;
NCIt definition : An orally bioavailable inhibitor of SRC family of kinases (SFK), including SRC and
YES1, with potential antineoplastic activity. Upon oral administration, SRC/YES1 kinase
inhibitor NXP900 targets, binds to, and locks SRC and YES1 into their native closed
conformation, thereby inhibiting both their kinase activity and their association
with protein signaling partners. This inhibits the oncogenic signaling pathways mediated
by these kinases and the proliferation of tumor cells overexpressing these kinases.
SRC family of kinases are upregulated in many tumor cells and play important roles
in tumor cell proliferation and metastasis.;
Molecule name : eCF506; NXP 900; NXP-900;
Origin ID : C200834;
concept_is_in_subset
- has_target
