Preferred Label : v-sis Platelet Derived Growth Factor, Beta Polypeptide;
NCIt synonyms : v-sis PDGF Beta Polypeptide;
NCIt definition : v-sis Platelet Derived Growth Factor beta polypeptide is the viral homologue of PDGFB.
Viral oncogenes originate from normal cellular genes by recombination between a parent
nontransforming virus and host cellular DNA; the cellular genes often code for important
functions in cell growth or tissue differentiation. PDGF is the major serum polypeptide
mitogen for cells of mesenchymal origin and has two dissimilar subunits, A and B.
The B chain has homology to SIS and is alone sufficient for mitogenesis. Most proliferating
cells are programmed to undergo apoptosis unless specific survival signals are provided.
PDGF promotes proliferation and inhibits apoptosis by activating the RAS/PIK3/AKT1/IKK/NFKB1
pathway, inducing putative anti-apoptotic genes. (from OMIM 190040 and NCI);
Origin ID : C20077;
UMLS CUI : C1337057;
Semantic type(s)
- gene_encodes_gene_product
- gene_product_has_organism_source
