Myelin-Oligodendrocyte Glycoprotein

Preferred Label : Myelin-Oligodendrocyte Glycoprotein;

NCIt synonyms : Myelin Oligodendrocyte Glycoprotein;

NCIt related terms : MOG;

NCIt definition : Myelin-oligodendrocyte glycoprotein (247 aa, 28 kDa) is encoded by the human MOG gene. This protein plays a role in the myelination and maintenance of the myelin sheath.;

Alternative definition : CDISC: An antigen encoded by the MOG gene and is involved in the myelination of nerves in the central nervous system. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases multiple sclerosis and other demyelinating diseases.;

NCIt note : Autoantibodies targeting myelin-oligodendrocyte glycoprotein are associated with autoimmune encephalomyelitis and multiple sclerosis.; Myelin-oligodendrocyte glycoprotein acts as a viral receptor for rubella virus. (UniProt);

Details

Origin ID

C200639;

UMLS CUI

C1506126;

OMIM relation
- Myelin-oligodendrocyte glycoprotein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MOG protein, human [MeSH Supplementary Concept]
- MOG protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MOG Gene [NCIt concept]
gene_product_has_associated_anatomy
- Myelin Sheath [NCIt concept]
- Oligodendrocyte [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Immunoglobulin Family Protein [NCIt concept]
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Carbohydrate Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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