NPM1/MLF1 Fusion Protein

Preferred Label : NPM1/MLF1 Fusion Protein;

NCIt synonyms : Nucleophosmin/Myeloid Leukemia Factor 1 Fusion Protein; NPM1-MLF1 Fusion Protein; NPM1::MLF1 Fusion Protein; NPM-MLF1 Fusion Protein;

NCIt definition : A fusion protein ( 54 kDa) encoded by the NPM1/MLF1 fusion gene. This protein contains 175 N-terminal domain amino acid residues from the nucleophosmin protein, including its dimerization domain and a nuclear localization signal, fused in frame with the myeloid leukemia factor 1 protein (MLF1). Since the nucleophosmin-derived sequences of the NPM1/MLF1 fusion protein can promote its nuclear localization, expression of this fusion protein may result in nuclear localization of MLF1 and lead to aberrant activation of MLF1-dependent transcription factor activity, which may stimulate the differentiation of hemopoietic progenitors into myeloid cells.;

NCI Metathesaurus CUI : CL1907459;

Details

Origin ID

C200451;

UMLS CUI

C5856252;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- NPM1/MLF1 Fusion Gene [NCIt concept]
related_to_genetic_biomarker
- MLF1 Gene [NCIt concept]
- NPM1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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