Preferred Label : RAF Inhibitor BDTX-4933;
NCIt synonyms : RAF Kinase Inhibitor BDTX-4933;
NCIt definition : A central nervous system (CNS)-penetrant inhibitor of the serine/threonine protein
kinase Raf family, with potential antineoplastic activity. Upon oral administration,
BDTX-4933 selectively targets, binds to and inhibits the activity of activated RAF
that results from BRAF monomeric (class I), and dimeric class II (Ras-independent)
and class III (Ras-dependent) mutations, and RAS mutations, which may inhibit the
proliferation of tumor cells expressing a mutated BRAF, KRAS or NRAS gene. Raf protein
kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated
in a variety of cancer cell types. They play key roles in tumor cell proliferation
and survival. BRAF, a serine/threonine protein kinase, plays a key role in regulating
the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to
BRAF gene mutations. Ras serves an important role in cell signaling, division and
differentiation. Mutations of Ras may induce constitutive signal transduction leading
to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : BDTX-4933; BDTX 4933;
NCI Metathesaurus CUI : CL1907323;
Origin ID : C200038;
concept_is_in_subset
- has_target
