Preferred Label : Anti-PD-1/Anti-ILT4 Bispecific Antibody CDX-585;
NCIt synonyms : Anti-PD-1/Anti-ILT4 Monoclonal Antibody CDX-585; Anti-PD-1/ILT4 Bispecific Antibody CDX-585; PD-1 x ILT4 Bispecific Antibody CDX-585; PD-1/ILT4 Dual Antagonist Monoclonal Antibody CDX-585;
NCIt definition : A humanized, dual antagonist immunoglobulin G1 kappa (IgG1K) monoclonal antibody directed
against the inhibitory immune checkpoint receptors programmed cell death protein 1
(PD-1; PDCD1; CD279) and ILT4 (immunoglobulin-like transcript 4; leukocyte immunoglobulin-like
receptor subfamily B member 2; LILRB2; lymphocyte immunoglobulin-like receptor 2;
LIR2; monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d), with potential
immunomodulating and antineoplastic activities. Upon administration, anti-PD-1/anti-ILT4
bispecific antibody CDX-585 targets and binds to both PD-1 and ILT4. The binding of
CDX-585 to PD-1 prevents the activation of PD-1 by its ligands, programmed cell death-1
ligand 1 (PD-L1; cluster of differentiation 274; CD274) and/or 2 (PD-L2). This abrogates
T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic
T-lymphocyte (CTL)-mediated tumor cell lysis, which may lead to a reduction in tumor
growth. The binding of CDX-585 to ILT4 prevents activation by its ligands, including
the major histocompatibility complex class I (MHC I) molecules human leukocyte antigen
(HLA)-A, HLA-B, HLA-C and HLA-G, and inhibits ILT4-mediated signaling. Dual checkpoint
blockade of PD-1 and ILT4 may enhance T-cell activation, activate expression of pro-inflammatory
cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF) and
tumor necrosis factor alpha (TNFalpha), and augment cytotoxic T-lymphocyte (CTL)-mediated
anti-tumor immune responses more than the blockade of either immune checkpoint receptor
alone. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed
on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation
and effector function when activated by its ligands PD-L1 or PD-L2; it plays an important
role in tumor evasion from host immunity. ILT4, a transmembrane protein and inhibitory
member of the immunoglobulin-like transcript (ILT) family of proteins, is expressed
primarily by myeloid cells, including monocytes, macrophages, dendritic cells (DCs)
and granulocytes, and certain tumor cells; it also plays a role in tumor evasion.;
Molecule name : CDX-585; CDX 585;
NCI Metathesaurus CUI : CL1906564;
Origin ID : C199672;
UMLS CUI : C5854457;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
