Cyclin D1-Positive Mantle Cell Lymphoma

Preferred Label : Cyclin D1-Positive Mantle Cell Lymphoma;

NCIt synonyms : Mantle Cell Lymphoma with CCND1 Translocation; Cyclin D1-Positive MCL; Mantle Cell Lymphoma with CCND1 Rearrangement;

NCIt definition : A molecular subtype of mantle cell lymphoma characterized by the presence of cyclin D1 expression and/or CCND1 rearrangement..;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1906844;

Details

Origin ID

C199481;

Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Lymphadenopathy [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- CCND1 Gene Rearrangement [NCIt concept]
- CCND1 Gene Translocation [NCIt concept]
- t(11;14)(q13;q32) [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte [NCIt concept]
disease_has_finding
- CCND1 Positive [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Peripheral B-Lymphocyte of Inner Mantle Zone [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
- Mantle Zone [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- CCND1 Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- CCND1 Gene [NCIt concept]
- CCND1 wt Allele [NCIt concept]

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