Preferred Label : Anti-DLL3/CD3/CD137 Trispecific Antibody RG6524;
NCIt synonyms : Anti-DLL3/CD3/CD137 Trispecific Antibody ALPS12; Anti-DLL3/CD3/CD137 Trispecific Antibody RO7616789;
NCIt definition : A trispecific T-cell engager antibody directed against the tumor-associated antigen
(TAA) delta-like protein 3 (DLL3), the T-cell costimulatory receptor CD137 (4-1BB;
tumor necrosis factor receptor superfamily member 9; TNFRSF9), and the T-cell surface
antigen CD3, with potential immunostimulating and antineoplastic activities. Upon
administration, anti-DLL3/CD3/CD137 trispecific antibody RG6524 binds to DLL3 expressed
on tumor cells, CD3 expressed on T-cells, and CD137 expressed on a variety of leukocyte
subsets including activated T-lymphocytes and natural killer (NK) cells. The binding
to DLL3 and CD3 activates and redirects cytotoxic T-lymphocytes (CTLs) to DLL3-expressing
tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor
cells. The binding to CD137 enhances CD137-mediated signaling, induces CTL proliferation
and cytokine production, and further promotes a CTL-mediated anti-tumor immune response
as well as induces NK-mediated tumor cell killing and suppresses the immunosuppressive
activity of regulatory T-cells (Tregs). CD137, a surface glycoprotein of the tumor
necrosis factor receptor superfamily, is an inducible costimulatory receptor that
plays a key role in T-cell proliferation, survival and cytolytic activity. DLL3, a
Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays
a key role in embryonic development and in tumor initiation and proliferation.;
Molecule name : RO-7616789; RO 7616789; ALPS-12; ALPS 12; RG-6524; RG 6524;
NCI Metathesaurus CUI : CL1905851;
Origin ID : C198701;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
