Aldehyde Dehydrogenase 3 Family

Preferred Label : Aldehyde Dehydrogenase 3 Family;

NCIt synonyms : ALDH3 Family; Aldehyde Dehydrogenase 3; ALDH3;

NCIt definition : A subfamily of the aldehyde dehydrogenase enzyme family that plays a role in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. Aberrant expression of these enzymes has been characterized in many cancer cell types and in cancer stem cells, where they may promote both cell survival and treatment resistance.;

NCIt note : The ALDH3 family includes proteins encoded by the human ALDH3A1, ALDH3A2, ALDH3B1 and ALDH3B2 genes.;

NCI Metathesaurus CUI : CL1913106;

Details

Origin ID

C193457;

UMLS CUI

C5782079;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Oxidoreductase [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- ALDH1/3 Inhibitor ABD-3001 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients