Preferred Label : ALDH1/3 Inhibitor ABD-3001;
NCIt synonyms : Dimethyl Ampal Thiolester; DIMATE;
NCIt definition : A suicidal inhibitor of aldehyde dehydrogenases 1 (ALDH1) and 3 (ALDH3), with potential
antineoplastic activity. Upon administration, ALDH1/3 inhibitor ABD-3001 targets,
binds to and irreversibly inhibits the activity of ALDH1 and ALDH3. This results in
the accumulation of reactive aldehydes in tumor cells, which interferes with oncogenic
signaling pathways and tumor cell proliferation. In addition, the inhibition of ALDH1
and ALDH3 disrupts glutathione redox balance in tumor cells, leading to oxidative
stress which may further promote tumor cell death.;
Molecule name : ABD-3001; ABD 3001;
NCI Metathesaurus CUI : CL1913098;
Origin ID : C193452;
UMLS CUI : C5785763;
Semantic type(s)
- concept_is_in_subset
- has_target
