Glutamate Decarboxylase

Preferred Label : Glutamate Decarboxylase;

NCIt synonyms : EC 4.1.1.15; Glutamic Acid Decarboxylase;

NCIt related terms : GAD;

NCIt definition : A lyase that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2), which uses pyridoxal-phosphate (PLP) as a cofactor. There are two human isoforms of glutamate decarboxylase that are responsible for maintaining the majority of the physiological supply of GABA.;

Alternative definition : CDISC: Any antigen(s) encoded by the GAD gene that catalyze the decarboxylation of glutamate to GABA. They can be considered as autoantigens and are commonly associated with the autoimmune diseases type 1 diabetes, autoimmune polyendocrine syndrome types 1 and 2, and stiff man syndrome.;

NCI Metathesaurus CUI : CL1913246;

Details

Origin ID

C193255;

UMLS CUI

C0017785;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Glutamate decarboxylase [LOINC component]
- Glutamate decarboxylase (substance) [SNOMED CT concept]
- glutamate decarboxylase [MeSH Descriptor]
- glutamate decarboxylase [MeSH concept]
- glutamate decarboxylase [SNOMED Notion]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Lyase Gene [NCIt concept]
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- Substrate Interaction Domain [NCIt concept]

Keyword's position in hierarchy(ies) :

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