glutamate decarboxylase

Preferred Label : glutamate decarboxylase;

MeSH definition : A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.;

MeSH synonym : acid decarboxylase, glutamic; glutamate carboxy-lyase; decarboxylase, glutamic acid; decarboxylase, glutamate; glutamic acid decarboxylase; carboxy-lyase, glutamate; glutamate carboxy lyase;

MeSH CAS label : L-Glutamate-1-carboxy-lyase;

Registry Number MeSH : EC 4.1.1.15;

Wikipedia link : https://en.wikipedia.org/wiki/Glutamate decarboxylase;

Is substance : O;

UNII : EC 4.1.1.15;

Details

Origin ID

D005968;

UMLS CUI

C0017785;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Glutamate decarboxylase (substance) [SNOMED CT concept]
- glutamate decarboxylase [SNOMED Notion]
Indexing information
- (2RS,3E)-2-methyl-3,4-didehydroglutamic acid [MeSH Supplementary Concept]
- 2-keto-4-pentenoic acid [MeSH Supplementary Concept]
- 4-bromoisophthalic acid [MeSH Supplementary Concept]
- N-gamma-glutamyldiaminopropionic acid [MeSH Supplementary Concept]
- pyridoxal phosphate gamma-glutamyl hydrazone [MeSH Supplementary Concept]
Record concept(s)
- glutamate decarboxylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- ERT D1 protein, lycopersicon esculentum [MeSH Supplementary Concept]
- GAD55, human [MeSH Supplementary Concept]
- GAD65 (217-236) [MeSH Supplementary Concept]
- GAD65 (524-543) [MeSH Supplementary Concept]
- GAD65 (96-585) [MeSH Supplementary Concept]
- GAD65(370-575), human [MeSH Supplementary Concept]
- aspartate-alpha-decarboxylase [MeSH Supplementary Concept]
- b protein, Drosophila [MeSH Supplementary Concept]
- gadA protein, E coli [MeSH Supplementary Concept]
- gadB protein, E coli [MeSH Supplementary Concept]
- glutamate decarboxylase 1 [MeSH Supplementary Concept]
- glutamate decarboxylase 2 [MeSH Supplementary Concept]
- glutamate decarboxylase 65 (202-221) [MeSH Supplementary Concept]
- glutamic acid decarboxylase 65 (524-543), mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Glutamate Decarboxylase [NCIt concept]
- Glutamate decarboxylase [LOINC component]
- Glutamate decarboxylase (substance) [SNOMED CT concept]
- glutamate decarboxylase [SNOMED Notion]

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