NCIt definition : A human immunoglobulin G1 (IgG1) Fc-silenced bispecific antibody directed against
the human negative immunoregulatory checkpoint receptors programmed cell death protein
1 (PD-1; PD1; PDCD1; CD279; programmed death 1) and lymphocyte activation gene 3 protein
(LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration, anti-LAG-3/PD-1 bispecific antibody INCA32459 targets
and binds to both PD-1 and LAG-3 expressed on T-cells and inhibits PD-1- and LAG-3-mediated
downregulation of T-cell activation and proliferation. This may lead to cytotoxic
T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play
key roles in suppressing T-cell activation and proliferation.;