NCIt definition : An orally bioavailable class 1 and 2 inhibitor of the serine/threonine-protein kinase
B-raf (BRAF) protein, with potential antineoplastic activity. Upon oral administration,
claturafenib selectively binds to and inhibits the activity of class 1 and 2 BRAF
alterations. This inhibits the proliferation of tumor cells which express these BRAF
alterations. BRAF, a member of the raf family of serine/threonine protein kinases,
plays a role in the regulation of mitogen-activated protein kinase (MAPK) and extracellular
signal-regulated kinase (ERK) signaling pathways, which may be constitutively activated
due to BRAF gene mutations. Mutated forms and fusions of BRAF are associated with
a number of neoplastic diseases.;
UNII : PC35M52J8T;
CAS number : 2754408-94-9;
Molecule name : ARRY-440; ARRY 440; PF-07799933; PF 07799933;