" /> Claturafenib - CISMeF





Preferred Label : Claturafenib;

NCIt synonyms : BRAF Inhibitor PF-07799933;

NCIt definition : An orally bioavailable class 1 and 2 inhibitor of the serine/threonine-protein kinase B-raf (BRAF) protein, with potential antineoplastic activity. Upon oral administration, claturafenib selectively binds to and inhibits the activity of class 1 and 2 BRAF alterations. This inhibits the proliferation of tumor cells which express these BRAF alterations. BRAF, a member of the raf family of serine/threonine protein kinases, plays a role in the regulation of mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) signaling pathways, which may be constitutively activated due to BRAF gene mutations. Mutated forms and fusions of BRAF are associated with a number of neoplastic diseases.;

UNII : PC35M52J8T;

CAS number : 2754408-94-9;

Molecule name : ARRY-440; ARRY 440; PF-07799933; PF 07799933;

NCI Metathesaurus CUI : CL1905425;

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04/05/2025


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