Serine Protease Inhibitor Kazal-Type 5

Preferred Label : Serine Protease Inhibitor Kazal-Type 5;

NCIt synonyms : SPINK5; Lymphoepithelial Kazal-Type-Related Inhibitor; Lympho-Epithelial Kazal-Type-Related Inhibitor; Serine Peptidase Inhibitor Kazal Type 5; LEKTI;

NCIt definition : Serine protease inhibitor Kazal-type 5 (1064 aa, 121 kDa) is encoded by the human SPINK5 gene. This protein plays a role in the negative regulation of proteolysis that promotes mucosal epithelia formation and keratinocyte terminal differentiation.;

NCI Metathesaurus CUI : CL340694;

Details

Origin ID

C191816;

UMLS CUI

C0908022;

OMIM relation
- Serine protease inhibitor, kazal-type, 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SPINK5 protein, human [MeSH Supplementary Concept]
- SPINK5 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SPINK5 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Enzyme Inhibition [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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