Preferred Label : Favezelimab/Pembrolizumab Formulation;
NCIt synonyms : Coformulated Favezelimab Plus Pembrolizumab; Coformulated Favezelimab/Pembrolizumab; Favezelimab/Pembrolizumab Formulation MK-4280A; Coformulated MK-4280 Plus MK-3475;
NCIt definition : A coformulation containing favezelimab, a humanized, immunoglobulin G4 (IgG4) monoclonal
antibody (MAb) directed against the inhibitory receptor lymphocyte activation gene-3
protein (LAG3), and pembrolizumab, a humanized monoclonal IgG4 antibody directed against
human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration
of the favezelimab/pembrolizumab formulation, favezelimab binds to LAG3 expressed
on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility
complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific
T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads
to a reduction in tumor growth. Pembrolizumab binds to PD-1, an inhibitory signaling
receptor expressed on the surface of activated T-cells, and blocks the binding to
and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated
immune responses against tumor cells LAG3, a member of the immunoglobulin superfamily
(IgSF) expressed on various immune cells, negatively regulates both proliferation
and activation of T-cells. Its expression on TILs is associated with tumor-mediated
immune suppression. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1),
overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2),
which is primarily expressed on antigen presenting cells (APCs). Activated PD-1 negatively
regulates T-cell activation and plays a key role in in tumor evasion from host immunity.;
Molecule name : MK 4280A; MK-4280A;
NCI Metathesaurus CUI : CL1799312;
Origin ID : C190780;
UMLS CUI : C5783930;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
