2'-5'-Oligoadenylate Synthase 3

Preferred Label : 2'-5'-Oligoadenylate Synthase 3;

NCIt synonyms : OAS3; 2-5A Synthetase 3; 2'-5'-Oligoadenylate Synthetase 3; (2-5')Oligo(A) Synthase 3; p100OAS; p100 OAS; 2'-5'Oligoadenylate Synthetase P100; 2-5A Synthase 3; EC 2.7.7.84; (2-5')Oligo(A) Synthetase 3;

NCIt definition : 2'-5'-oligoadenylate synthase 3 (1087 aa, 121 kDa) is encoded by the human OAS3 gene. This protein is involved in innate antiviral responses.;

NCIt note : 2'-5'-oligoadenylate synthase 3 exhibits antiviral activity against Chikungunya virus, Dengue virus, Sindbis virus and Semliki forest virus. (UniProt);

Details

Origin ID

C190131;

UMLS CUI

C3529512;

Automatic exact mappings (from CISMeF team)
- 2'-5'-oligoadenylate synthetase 3 [HGNC gene]
- 2-prime,5-prime-oligoadenylate synthetase 3 [OMIM gene]
OMIM relation
- 2-prime,5-prime-oligoadenylate synthetase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- OAS3 protein, human [MeSH Supplementary Concept]
- OAS3 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- OAS3 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Extracellular Space [NCIt concept]
- Nucleoplasm [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- NOD-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Immunity [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- RNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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