Inter-Alpha-Trypsin Inhibitor Light Chain

Preferred Label : Inter-Alpha-Trypsin Inhibitor Light Chain;

NCIt synonyms : EDC1; ITIL; Inter-Alpha-Trypsin Inhibitor, Light Chain; Uronic-Acid-Rich Protein; IATIL; Inter-Alpha-Inhibitor Light Chain; Bikunin; ITI-LC; HI-30;

NCIt definition : Inter-alpha-trypsin inhibitor light chain (147 aa, 16 kDa) is encoded by the human AMBP gene. This protein plays a role in serine protease inhibition and the structure of hyaluronan-rich extracellular matrices.;

NCIt note : Inter-alpha-trypsin inhibitor light chain is comprised of amino acid residues 206-352 of protein AMBP. (UniProt); The formation of I-alpha-I plasma protease inhibitor complexes having one inter-alpha-trypsin inhibitor light chain (ITI-LC) and one or two ITI-heavy chains (HC) is required for serine protease inhibitor activity. Inter-alpha-inhibitor (I-alpha-I) is a heterotrimer containing ITIH1/HC1, ITIH2/HC2 and ITI-LC, and pre-alpha-inhibitor (P-alpha-I) is a heterodimer of ITIH3/HC3 and ITI-LC. (UniProt);

NCI Metathesaurus CUI : CL1798816;

Details

Origin ID

C190097;

UMLS CUI

C5781085;

Automatic exact mappings (from CISMeF team)
- Alpha-1 microglobulin/bikunin precursor [OMIM gene]
- alpha-1-microglobulin/bikunin precursor [HGNC gene]
OMIM relation
- Alpha-1 microglobulin/bikunin precursor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- AMBP Gene [NCIt concept]
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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