Creatine Kinase M-Type

Preferred Label : Creatine Kinase M-Type;

NCIt synonyms : Creatine Kinase M Chain; CPK-M; EC 2.7.3.2; CKM; Creatine Phosphokinase M-Type; M-CK;

NCIt definition : Creatine kinase M-type (381 aa, 43 kDa) is encoded by the human CKM gene. This protein plays a role in the transfer of a phosphate group from ATP to creatine and other phosphagens.;

NCIt note : Creatine kinase M-type forms dimers of identical or non-identical isoenzymes. With the MM homodimer being the major form in skeletal muscle and myocardium and the MB heterodimer existing in myocardium. (UniProt);

NCI Metathesaurus CUI : CL1798841;

Details

Origin ID

C190065;

UMLS CUI

C5780724;

Automatic exact mappings (from CISMeF team)
- Creatine kinase, muscle type [OMIM gene]
- creatine kinase, M-type [HGNC gene]
OMIM relation
- Creatine kinase, muscle type [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- CKM Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arginine and Proline Metabolism Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Energy Metabolism Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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