" /> Siremadlin Succinate - CISMeF





Preferred Label : Siremadlin Succinate;

NCIt synonyms : HDM201 Succinate; NVP-HDM201-BBA;

NCIt definition : The succinate form of siremadlin, an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. Siremadlin inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.;

UNII : 0XPX99P4ZT;

CAS number : 1638193-48-2;

NCI Metathesaurus CUI : CL1798506;

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30/07/2025


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