NCIt definition : The succinate form of siremadlin, an orally bioavailable human double minute 2 homolog
(HDM2) inhibitor with potential antineoplastic activity. Siremadlin inhibits the binding
of the HDM2 protein to the transcriptional activation domain of the tumor suppressor
protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic
degradation of p53 is inhibited, which may result in the restoration of both p53 signaling
and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and
negative regulator of the p53 pathway, is often overexpressed in cancer cells and
has been implicated in cancer cell proliferation and survival.;
Semantic type(s)