Siremadlin - CISMeF

Preferred Label : Siremadlin;

NCIt synonyms : NVP-HDM 201;

NCIt definition : An orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. Siremadlin inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.;

UNII : 0282IF4JC8;

InChIKey : AGBSXNCBIWWLHD-FQEVSTJZSA-N;

CAS number : 1448867-41-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1448867-41-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : HDM201;

NCI Metathesaurus CUI : CL473659;

Details

Origin ID

C116325;

UMLS CUI

C5227584;

Automatic exact mappings (from CISMeF team)
- siremadlin [MeSH concept]
- siremadlin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- siremadlin [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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