Preferred Label : Anti-PD-1/IL-2 Bispecific Antibody Fusion Protein IBI363;
NCIt synonyms : PD-1/IL-2 Bispecific Molecule IBI363; Fusion Protein IBI363; Anti-PD-1/IL-2 Bispecific Fusion Protein IBI363;
NCIt definition : A bispecific antibody fusion protein composed of a monoclonal antibody targeting the
negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1;
PDCD1; CD279) and fused to a mutated form of the endogenous cytokine interleukin-2
(IL-2), with potential immunostimulating and antineoplastic activities. Upon administration,
anti-PD-1/IL-2 bispecific antibody fusion protein IBI363 targets and binds to PD-1
expressed on PD-1-expressing T-cells, thereby inhibiting PD-1-mediated signaling.
This may restore immune function through the activation of T-cells and T-cell-mediated
immune responses against tumor cells. IL-2 targets and binds to the IL-2 receptor
IL2R and activates IL-2/IL-2R-mediated signaling, which further activates cytotoxic
T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain
cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta
(TGFb). This further enhances T-cell-mediated cytotoxic immune responses against tumor
cells. By selectively activating PD-1 positive T-cells by IL-2, but not PD-1 negative
bystander or naïve T cells, the activity of tumor specific T-cells is specifically
enhanced while IL-2-induced systemic toxicity is decreased. PD-1, a transmembrane
protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as
an immune checkpoint that negatively regulates T-cell activation and effector function
when activated by its ligands programmed cell death-1 ligand 1 (PD-L1; cluster of
differentiation 274; CD274) or 2 (PD-L2); it plays an important role in tumor evasion
from host immunity.;
Molecule name : IBI 363; IBI-363;
NCI Metathesaurus CUI : CL1798640;
Origin ID : C189813;
UMLS CUI : C5706549;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
