Preferred Label : Anti-CD19/Anti-CD70 4SCAR-expressing Bispecific T-cells;
NCIt synonyms : Anti-CD19/CD70 Bispecific 4SCAR T-cells; Anti-CD19/Anti-CD70 4SCAR T-cells; Bi-specific CD19/70 4SCAR-T Cells; CD19/70 Bi-specific 4SCAR-T Cells; Bi-4SCAR CD19/70 T-cells;
NCIt definition : A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation
chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs)
CD19 and CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7), with
potential immunostimulating and antineoplastic activities. Upon administration, the
anti-CD19/anti-CD70 4SCAR-expressing bispecific T-cells are directed to and induce
selective toxicity in CD19- and CD70-expressing tumor cells. CD19 antigen is a B-cell
specific cell surface antigen expressed in all B-cell lineage malignancies. CD70,
a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for
the costimulatory receptor CD27, is expressed on the surfaces of various types of
cancer cells; its overexpression may play an important role in the evasion of immune
surveillance. CD19 and CD70 are expressed at high levels on tumor cells but not at
significant levels on normal tissues. Targeting two antigens may protect against antigen
escape and may enhance CAR-T cell efficacy.;
NCI Metathesaurus CUI : CL1794268;
Origin ID : C189058;
UMLS CUI : C5708220;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
