SARS-CoV-2 Spike Protein S2

Preferred Label : SARS-CoV-2 Spike Protein S2;

NCIt synonyms : SARS2 Spike Protein S2; Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein S2; Spike Protein S2; Spike 2; S2 Subunit;

NCIt related terms : S2;

NCIt definition : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein 2 (588 aa, 65 kDa) is encoded by the SARS-CoV-2 S gene. This protein plays a role in internalization by or fusion with host cell membranes.;

NCIt note : SARS-CoV-2 spike glycoprotein is sequentially cleaved to form spike protein S1 (amino acid residues 13-685), spike protein S2 (residues 686-1273) and spike protein S2' (residues 816-1273). S1 binds to angiotensin-converting enzyme 2, while S2 and S2' mediate fusion of the virion and cellular membranes. (UniProt);

NCI Metathesaurus CUI : CL1794630;

Details

Origin ID

C188488;

UMLS CUI

C5707812;

Automatic exact mappings (from CISMeF team)
- S2 subunit [COVID-19 Thesaurus concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
- SeroNet Authorized Values [NCIt concept]
- SeroNet Study Descriptors [NCIt concept]
gene_encodes_gene_product
- SARS-CoV-2 S Gene [NCIt concept]
- Viral Gene [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Virus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Virus-Cell Membrane Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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