Preferred Label : Rilvegostomig;
NCIt synonyms : PD-1 x TIGIT Bispecific Antibody AZD2936; Anti-PD-1/TIGIT Bispecific Antibody AZD2936; Anti-TIGIT/Anti-PD-1 Bispecific Antibody AZD2936; TIGIT/PD-1 Bispecific Antibody AZD2936; Anti-PD-1/Anti-TIGIT Bispecific Antibody AZD2936;
NCIt definition : A bispecific antibody directed against the negative immunoregulatory human cell receptor
programmed cell death protein 1 (PD-1; PDCD1; CD279) and the co-inhibitory molecule
and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and
immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, rilvegostomig
simultaneously targets, binds to and inhibits PD-1 and TIGIT and their downstream
signaling pathways. Inhibition of PD-1-mediated signaling may restore immune function
through the activation of T-cells and T-cell-mediated immune responses. Inhibition
of TIGIT expressed on various immune cells, particularly on tumor-infiltrating lymphocytes
(TILs), prevents the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus
receptor related-2; PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like
protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with the costimulatory
receptor CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells,
such as natural killer (NK) cells and CD8 T-cells. This leads to CD226 dimerization
and CD226-mediated signaling and activates the immune system to exert a T-cell-mediated
immune response against cancer cells. PD-1, a transmembrane protein in the immunoglobulin
superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively
regulates T-cell activation and effector function when activated by its ligands programmed
cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion
from host immunity. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory
receptor, plays a key role in the suppression of T-cell proliferation and activation;
it is involved in tumor cell immune evasion, and the inhibition of antiviral immune
responses.;
UNII : YSL2GUT2Q8;
CAS number : 2640305-01-5;
Molecule name : AZD 2936; AZD-2936;
NCI Metathesaurus CUI : CL1793114;
Origin ID : C188211;
UMLS CUI : C5707665;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
