EGFR Inhibitor NRC-2694

Preferred Label : EGFR Inhibitor NRC-2694;

NCIt related terms : NRC-2694;

NCIt definition : An orally bioavailable, small-molecule inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, EGFR inhibitor NRC-2694 binds to and inhibits EGFR, which prevents EGFR-mediated signaling and leads to cell death in EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.;

UNII : O898S9836V;

CAS number : 936446-61-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 936446-61-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : NRC 2694; NRC-2694;

NCI Metathesaurus CUI : CL1779201;

Details

Origin ID

C187045;

UMLS CUI

C5667106;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- EGFR Inhibitor NRC-2694 Dihydrochloride [NCIt concept]
- EGFR Inhibitor NRC-2694 Hydrochloride [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
is_free_acid_or_base_form_of
- EGFR Inhibitor NRC-2694 Dihydrochloride [NCIt concept]
- EGFR Inhibitor NRC-2694 Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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