SPI1 Oncoprotein

Preferred Label : SPI1 Oncoprotein;

NCIt definition : SPI1 is a putative oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus. It encodes PU.1, an ETS-domain transcription factor normally expressed in all hematopoietic lineages except in T-cells, and is essential for myeloid (osteoclast progenitors) and B-lymphoid cell development. A low concentration of PU.1 induces the B-cell fate, whereas a high concentration promotes macrophage differentiation. (from OMIM 165170 and NCI);

Details

Origin ID

C18555;

UMLS CUI

C0919492;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Oncogene [NCIt concept]
- Oncogene SPI1 [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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