Methyl-CpG-Binding Domain Protein 2

Preferred Label : Methyl-CpG-Binding Domain Protein 2;

NCIt synonyms : Demethylase; Methyl-CpG-Binding Protein MBD2; MBD2; Methyl-CpG Binding Domain Protein 2; DMTase;

NCIt definition : Methyl-CpG-binding domain protein 2 (411 aa, 43 kDa) is encoded by the human MBD2 gene. This protein is involved in DNA methylation-mediated transcriptional regulation.;

NCIt note : Methyl-CpG-binding domain protein 2 specifically binds to CpG islands in promoters where position 5 of the cytosine is methylated. (UniProt);

Details

Origin ID

C183561;

UMLS CUI

C1454679;

Automatic exact mappings (from CISMeF team)
- Dipeptidase 2 [OMIM gene]
- MBD2 protein [MeSH Supplementary Concept]
- Methyl-cpg-binding domain protein 2 [OMIM gene]
- methyl-CpG binding domain protein 2 [HGNC gene]
OMIM relation
- Methyl-cpg-binding domain protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MBD2 protein, human [MeSH Supplementary Concept]
- MBD2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- MBD2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- HDAC Class I Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- DNA Methylation Regulation [NCIt concept]
- Ligand Binding [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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