Small G Protein

Preferred Label : Small G Protein;

NCIt definition : A class of small GTP-binding regulatory proteins regulated by G protein coupled receptors that act as switches in signal transduction pathways. The nature of the nucleotide bound to the protein determines its activity: GTP in the active state, GDP in the inactive state. The prototype for this class of proteins is the cellular proto-oncogene RAS.;

Details

Origin ID

C18277;

UMLS CUI

C0751984;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- monomeric GTP-Binding proteins [MeSH Descriptor]
- monomeric GTP-Binding proteins [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- GTPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
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- GTP Binding [NCIt concept]
- Hydrolysis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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