Preferred Label : Anti-PD-1/Anti-TIGIT Bispecific Antibody IBI321;
NCIt synonyms : Anti-PD-1/TIGIT Bispecific Antibody IBI321; PD-1 x TIGIT Bispecific Antibody IBI321;
NCIt definition : A bispecific antibody directed against the negative immunoregulatory human cell receptor
programmed cell death protein 1 (PD-1; PDCD1; CD279) and the co-inhibitory molecule
and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and
immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, the
anti-PD-1/anti-TIGIT bispecific antibody IBI321 simultaneously targets, binds to and
inhibits PD-1 and TIGIT and their downstream signaling pathways. Inhibition of PD-1-mediated
signaling may restore immune function through the activation of T-cells and T-cell-mediated
immune responses. Inhibition of TIGIT expressed on various immune cells, particularly
on tumor-infiltrating lymphocytes (TILs), prevents the interaction of TIGIT with its
ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus
receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction of CD112
and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1),
which is expressed on immune cells, such as natural killer (NK) cells and CD8 T-cells.
This leads to CD226 dimerization and CD226-mediated signaling and activates the immune
system to exert a T-cell-mediated immune response against cancer cells. PD-1, a transmembrane
protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as
an immune checkpoint that negatively regulates T-cell activation and effector function
when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2);
it plays an important role in tumor evasion from host immunity. TIGIT, a member of
the Ig super family (IgSF) and an immune inhibitory receptor, plays a key role in
the suppression of T-cell proliferation and activation; it is involved in tumor cell
immune evasion, and the inhibition of antiviral immune responses.;
Molecule name : IBI-321; IBI 321;
NCI Metathesaurus CUI : CL1663645;
Origin ID : C180907;
UMLS CUI : C5556708;
Semantic type(s)
chemical_or_drug_has_mechanism_of_action
concept_is_in_subset
has_target