Preferred Label : Leukotriene D4;
NCIt synonyms : (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-Amino-3-[(Carboxymethyl)Amino]-3-Oxopropyl}Sulfanyl)-5-Hydroxyicosa-7,9,11,14-Tetraenoic
Acid; (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-Hydroxybutyl)-2,4,6,9-Pentadecatetraenyl)-L-Cysteinyl)Glycine; LTD4; 5S-Hydroxy-6R-(S-Cysteinylglycinyl)-7E,9E,11E,14Z-Eicosatetraenoic Acid; S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-Hydroxybutyl]Pentadeca-2,4,6,9-Tetraen-1-Yl}-L-Cysteinylglycine; Glycine, N-(S-(1-(4-Carboxy-1-Hydroxybutyl)-2,4,6,9-Pentadecatetraenyl)-L-Cysteinyl)-,
(R-(R*,S*-(E,E,Z,Z)))-;
NCIt definition : A leukotriene synthesized from leukotriene C4 secreted by basophils via removal of
a glutamic acid group by cell surface proteases. Leukotriene D4 (LTD4) induces the
contraction of smooth muscle cells, which results in bronchoconstriction and vasoconstriction,
and increases vascular permeability. LTD4 can be further cleaved by cell surface proteases
that remove a glycine group to form leukotriene E4.;
UNII : 5FNY4416UE;
CAS number : 73836-78-9;
Chemical formula : C25H40N2O6S;
NCI Metathesaurus CUI : CL1663316;
ChEBI ID : CHEBI:28666;
Origin ID : C180700;
UMLS CUI : C0023544;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
