Temuterkib Mesylate

Preferred Label : Temuterkib Mesylate;

NCIt synonyms : LY-3214996 Mesylate; ERK1/2 Inhibitor LY3214996 Mesylate; LY3214996 Mesylate; LY 3214996 Mesylate;

NCIt definition : The mesylate salt form of temuterkib, an orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, temuterkib inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.;

UNII : 34M62WSA87;

CAS number : 2365171-00-0;

NCI Metathesaurus CUI : CL1663436;

Détails

Origin ID

C180622;

UMLS CUI

C5556505;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Temuterkib [NCIt concept]
has_target
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
is_salt_form_of
- Temuterkib [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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