" /> Temuterkib Mesylate - CISMeF





Preferred Label : Temuterkib Mesylate;

NCIt synonyms : LY-3214996 Mesylate; ERK1/2 Inhibitor LY3214996 Mesylate; LY3214996 Mesylate; LY 3214996 Mesylate;

NCIt definition : The mesylate salt form of temuterkib, an orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, temuterkib inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.;

UNII : 34M62WSA87;

CAS number : 2365171-00-0;

NCI Metathesaurus CUI : CL1663436;

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30/07/2025


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