Preferred Label : Temuterkib Mesylate;
NCIt synonyms : LY-3214996 Mesylate; ERK1/2 Inhibitor LY3214996 Mesylate; LY3214996 Mesylate; LY 3214996 Mesylate;
NCIt definition : The mesylate salt form of temuterkib, an orally available inhibitor of extracellular
signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon
oral administration, temuterkib inhibits both ERK 1 and 2, thereby preventing the
activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction
pathways. This results in the inhibition of ERK-dependent tumor cell proliferation
and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell
types and plays a key role in tumor cell proliferation, differentiation and survival.;
UNII : 34M62WSA87;
CAS number : 2365171-00-0;
NCI Metathesaurus CUI : CL1663436;
Origin ID : C180622;
UMLS CUI : C5556505;
Semantic type(s)
- concept_is_in_subset
- has_target
