Preferred Label : Temuterkib;
NCIt synonyms : ERK1/2 Inhibitor LY3214996;
NCIt definition : An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and
2, with potential antineoplastic activity. Upon oral administration, temuterkib inhibits
both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase
(MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of
ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often
upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation,
differentiation and survival.;
UNII : V0Q46LFE6F;
CAS number : 1951483-29-6;
Molecule name : LY 3214996; LY-3214996;
NCI Metathesaurus CUI : CL514490;
Origin ID : C131335;
UMLS CUI : C5554538;
Semantic type(s)
- concept_is_in_subset
- has_target
