Rhombotin-2 - CISMeF

Preferred Label : Rhombotin-2;

NCIt synonyms : LIM Domain Only 2; T-Cell Translocation Gene 2 Protein; Rhombotin 2; LIM-Only Protein 2; LIM Domain Only Protein 2; Lim Domain Only 2 Protein; Rhombotin-Like 1; LMO2; T-Cell Translocation Protein; TTG-2 Protein; Cysteine-Rich Protein TTG-2; LMO-2; Rhombotin-Like 1 Protein; LMO2 Protein; Rhombotin 2 Protein; T-Cell Translocation Protein 2;

NCIt definition : Rhombotin-2 (158 aa, 18 kDa) is encoded by the human LMO2 gene. This protein is involved in erythrocyte development.;

NCIt note : With two LIM domains and a cysteine-rich motif, rhombotin 2 is part of a multi-protein transcription regulatory complex that includes GATA-1. LMO2 protein binds to the bHLH TAL1 protein and interacts with retinoblastoma binding protein-2, enhancing transcription.;

Details

Origin ID

C17974;

UMLS CUI

C0250437;

OMIM relation
- Lim domain only 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- LMO2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- LIM Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Lymphoblastic Leukemia [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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