NF-AT - CISMeF

Preferred Label : NF-AT;

NCIt synonyms : Nuclear Factor of Activated T-cells; NFAT-1;

NCIt definition : NFAT is a multi-subunit transcription complex that includes homo- or hetero-dimers of FOS and JUN proteins. NFATC, the Dorsal/Rel family cytosolic component of NFAT, is translocated to the nucleus following TCR-induced PKC stimulation and calmodulin-dependent calcineurin-mediated dephosphorylation. Phosphoprotein NFATP, the 'preexisting component' of NFAT present in the unstimulated T-cell cytosol, locates in the nucleus as part of NFAT after activation.;

Details

Origin ID

C17903;

UMLS CUI

C0288011;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_expressed_in_tissue
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
has_gene_product_element
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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